Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype
Joint Authors
Markou, Konstantinos
Gerofotis, A.
Vital, Iosif
Veros, Konstantinos
Psillas, George
Daniilidis, M.
Vasilaki, A.
Source
Case Reports in Otolaryngology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Sudden sensorineural hearing loss may be present as a symptom in systemic autoimmune diseases or may occur as a primary disorder without another organ involvement (autoimmune inner ear disease).
The diagnosis of autoimmune inner ear disease is still predicated on clinical features, and to date specific diagnostic tests are not available.
We report a case of bilateral sudden hearing loss, tinnitus, intense rotatory vertigo, and nausea in a female patient in which the clinical manifestations, in addition to raised levels of circulating immune complexes, antithyroglobulin antibodies, and the presence of the HLA A1-B8-DR3 haplotype, allowed us to hypothesize an autoimmune inner ear disease.
Cyclosporine-A immunosuppressive treatment in addition to steroids helped in hearing recovery that occurred progressively with normalization of the hearing function after a five-month treatment.
Cyclosporine-A could be proposed as a therapeutic option in case of autoimmune inner ear disease allowing the suspension of corticosteroids that, at high dose, expose patients to potentially serious adverse events.
American Psychological Association (APA)
Psillas, George& Daniilidis, M.& Gerofotis, A.& Veros, Konstantinos& Vasilaki, A.& Vital, Iosif…[et al.]. 2013. Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype. Case Reports in Otolaryngology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-483199
Modern Language Association (MLA)
Psillas, George…[et al.]. Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype. Case Reports in Otolaryngology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-483199
American Medical Association (AMA)
Psillas, George& Daniilidis, M.& Gerofotis, A.& Veros, Konstantinos& Vasilaki, A.& Vital, Iosif…[et al.]. Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype. Case Reports in Otolaryngology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-483199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483199