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The Natural Antioxidants, Pomegranate Extract and Soy Isoflavones, Favourably Modulate Canine Endothelial Cell Function
Joint Authors
Ginouvès-Guerdoux, Amandine
Freudenthaler, Angelika
Gatto, Hugues
Waldenberger, Ferdinand Rudolf
Mcgahie, David
Baumgartner-Parzer, Sabina M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiovascular disease, preceded by vascular endothelial dysfunction, is a prominent cause of death in dogs.
L-carnitine and taurine, well known for their antioxidative capacity, beneficially affect cardiovascular disease as well as certain dog cardiomyopathies.
It is well established that vascular endothelial dysfunction precedes cardiovascular disease and that “vasoprotective factors” (NO and antioxidants) prevent apoptosis, whereas “risk factors” such as oxidized LDL, hyperglycemia, and free fatty acids trigger it in cultured human vascular endothelial cells.
Whereas human vascular cell in vitro models are widely established and used for the characterisation of potential vasoprotective substances, such models are not available for canine endothelial cells.
In the present study we therefore developed an in vitro model, which allows the testing of the effects of different substances on proliferation and apoptosis in canine aortic endothelial cells.
This model was used to test L-carnitine, taurine, pomegranate extract, and Soy Isoflavones in comparison to reference substances (glutathione and pioglitazone) previously shown to modulate human endothelial cell function.
L-carnitine and taurine neither exhibited antiproliferative nor antiapoptotic activities in the context of this study.
However extracts from pomegranate and soy isoflavones dramatically reduced proliferation and apoptosis in a dose dependent fashion, being in line with a vasoprotective activity in dogs.
American Psychological Association (APA)
Baumgartner-Parzer, Sabina M.& Waldenberger, Ferdinand Rudolf& Freudenthaler, Angelika& Ginouvès-Guerdoux, Amandine& Mcgahie, David& Gatto, Hugues. 2012. The Natural Antioxidants, Pomegranate Extract and Soy Isoflavones, Favourably Modulate Canine Endothelial Cell Function. ISRN Veterinary Science،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483221
Modern Language Association (MLA)
Baumgartner-Parzer, Sabina M.…[et al.]. The Natural Antioxidants, Pomegranate Extract and Soy Isoflavones, Favourably Modulate Canine Endothelial Cell Function. ISRN Veterinary Science No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-483221
American Medical Association (AMA)
Baumgartner-Parzer, Sabina M.& Waldenberger, Ferdinand Rudolf& Freudenthaler, Angelika& Ginouvès-Guerdoux, Amandine& Mcgahie, David& Gatto, Hugues. The Natural Antioxidants, Pomegranate Extract and Soy Isoflavones, Favourably Modulate Canine Endothelial Cell Function. ISRN Veterinary Science. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483221