Synchronization by Food Access Modifies the Daily Variations in Expression and Activity of Liver GABA Transaminase

Joint Authors

Vázquez-Martínez, Olivia
De Ita-Pérez, Dalia
Villalobos-Leal, Mónica
Méndez, Isabel
Díaz-Muñoz, Mauricio

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-04-07

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Daytime restricted feeding (DRF) is an experimental protocol that influences the circadian timing system and underlies the expression of a biological clock known as the food entrained oscillator (FEO).

Liver is the organ that reacts most rapidly to food restriction by adjusting the functional relationship between the molecular circadian clock and the metabolic networks.

γ-Aminobutyric acid (GABA) is a signaling molecule in the liver, and able to modulate the cell cycle and apoptosis.

This study was aimed at characterizing the expression and activity of the mostly mitochondrial enzyme GABA transaminase (GABA-T) during DRF/FEO expression.

We found that DRF promotes a sustained increase of GABA-T in the liver homogenate and mitochondrial fraction throughout the entire day-night cycle.

The higher amount of GABA-T promoted by DRF was not associated to changes in GABA-T mRNA or GABA-T activity.

The GABA-T activity in the mitochondrial fraction even tended to decrease during the light period.

We concluded that DRF influences the daily variations of GABA-T mRNA levels, stability, and catalytic activity of GABA-T.

These data suggest that the liver GABAergic system responds to a metabolic challenge such as DRF and the concomitant appearance of the FEO.

American Psychological Association (APA)

De Ita-Pérez, Dalia& Méndez, Isabel& Vázquez-Martínez, Olivia& Villalobos-Leal, Mónica& Díaz-Muñoz, Mauricio. 2014. Synchronization by Food Access Modifies the Daily Variations in Expression and Activity of Liver GABA Transaminase. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483250

Modern Language Association (MLA)

De Ita-Pérez, Dalia…[et al.]. Synchronization by Food Access Modifies the Daily Variations in Expression and Activity of Liver GABA Transaminase. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-483250

American Medical Association (AMA)

De Ita-Pérez, Dalia& Méndez, Isabel& Vázquez-Martínez, Olivia& Villalobos-Leal, Mónica& Díaz-Muñoz, Mauricio. Synchronization by Food Access Modifies the Daily Variations in Expression and Activity of Liver GABA Transaminase. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483250

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-483250