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Pharmacodynamic Modelling of Biomarker Data in Oncology
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The development of pharmacodynamic (PD) biomarkers in oncology has implications for design of clinical protocols from preclinical data and for predicting clinical outcomes from early clinical data.
Two classes of biomarkers have received particular attention.
Phosphoproteins in biopsy samples are markers of inhibition of signalling pathways, target sites for many novel agents.
Biomarkers of apoptosis in plasma can measure tumour cell killing by drugs in phase I clinical trials.
The predictive power of PD biomarkers is enhanced by data modelling.
With pharmacokinetic models, PD models form PK/PD models that predict the time course both of drug concentration and drug effects.
If biomarkers of drug toxicity are also measured, the models can predict drug selectivity as well as efficacy.
PK/PD models, in conjunction with disease models, make possible virtual clinical trials, in which multiple trial designs are assessed in silico, so the optimal trial design can be selected for experimental evaluation.
American Psychological Association (APA)
Jackson, Robert C.. 2012. Pharmacodynamic Modelling of Biomarker Data in Oncology. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-483258
Modern Language Association (MLA)
Jackson, Robert C.. Pharmacodynamic Modelling of Biomarker Data in Oncology. ISRN Pharmacology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-483258
American Medical Association (AMA)
Jackson, Robert C.. Pharmacodynamic Modelling of Biomarker Data in Oncology. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-483258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483258