A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder : Possible Relationship with Antiribosomal P Antibodies

Abstract EN

Complex movement disorder is a relatively rare presentation of neurolupus.

Antiphospholipid antibodies are associated with movement disorders likely via aberrant neuronal stimulation.

Antiribosomal P antibodies have been previously associated with neuropsychiatric disorders but their correlation with movement disorder was not previously established.

Our case report involves a 17-year-old Caucasian female patient positive for only antiribosomal P antibody and lupus anticoagulant who presented with a sudden onset of complex movement disorder.

After complete cessation of physical signs with olanzapine, anticardiolipin and anti-β2 glycoprotein I antibodies became positive which indicates a likely discordance between movement disorder and antiphospholipid antibodies.

This also indicates a potential causal role of antiribosomal P antibodies in inducing movement disorder.