Development of Th1 Imprints to rBCG Expressing a Foreign Protein : Implications for Vaccination against HIV-1 and Diverse Influenza Strains
Joint Authors
Marfleet, Travis W.
Power, Carl
Xiao, Wei
Qualtiere, Louis
Bretscher, Peter
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We demonstrate here that immunizing naïve mice with low numbers of recombinant Bacille Calmette-Guérin (rBCG) expressing β-galactosidase (β-gal) generates predominant Th1 responses to both BCG and β-gal whereas infection with high numbers generates a mixed Th1/Th2 response to both BCG and β-gal.
Furthermore, the Th1 response to both BCG and β-gal is stable when mice, pre-exposed to low numbers of rBCG, are challenged four months later with high numbers of rBCG.
Thus the Th1/Th2 phenotypes of the immune responses to β-gal and to BCG are “coherently” regulated.
Such rBCG vectors, encoding antigens of pathogens preferentially susceptible to cell-mediated attack, may be useful in vaccinating against such pathogens.
We discuss vaccination strategies employing rBCG vectors that are designed to provide protection against diverse influenza strains or numerous variants of HIV-1 and consider what further experiments are essential to explore the possibility of realizing such strategies.
American Psychological Association (APA)
Power, Carl& Marfleet, Travis W.& Qualtiere, Louis& Xiao, Wei& Bretscher, Peter. 2010. Development of Th1 Imprints to rBCG Expressing a Foreign Protein : Implications for Vaccination against HIV-1 and Diverse Influenza Strains. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-483323
Modern Language Association (MLA)
Power, Carl…[et al.]. Development of Th1 Imprints to rBCG Expressing a Foreign Protein : Implications for Vaccination against HIV-1 and Diverse Influenza Strains. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-483323
American Medical Association (AMA)
Power, Carl& Marfleet, Travis W.& Qualtiere, Louis& Xiao, Wei& Bretscher, Peter. Development of Th1 Imprints to rBCG Expressing a Foreign Protein : Implications for Vaccination against HIV-1 and Diverse Influenza Strains. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-483323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483323