γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein : Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
Joint Authors
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
γ-Secretase cleaves the carboxyl-terminal fragment (βCTF) of APP not only in the middle of the transmembrane domain (γ-cleavage), but also at sites close to the membrane/cytoplasm boundary (ε-cleavage), to produce the amyloid β protein (Aβ) and the APP intracellular domain (AICD), respectively.
The AICD49–99 and AICD50–99 species were identified as counterparts of the long Aβ species Aβ48 and Aβ49, respectively.
We found that Aβ40 and AICD50–99 were the predominant species in cells expressing wild-type APP and presenilin, whereas the production of Aβ42 and AICD49–99 was enhanced in cells expressing familial Alzheimer’s disease mutants of APP and presenilin.
These long Aβ species were identified in cell lysates and mouse brain extracts, which suggests that ε-cleavage is the first cleavage of βCTF to produce Aβ by γ-secretase.
Here, we review the progress of research on the mechanism underlying the proteolysis of the APP transmembrane domain based on tri- and tetrapeptide release.
American Psychological Association (APA)
Takami, Mako& Funamoto, Satoru. 2012. γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein : Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-483330
Modern Language Association (MLA)
Takami, Mako& Funamoto, Satoru. γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein : Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-483330
American Medical Association (AMA)
Takami, Mako& Funamoto, Satoru. γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein : Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-483330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483330