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Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population
Joint Authors
Barclay, Murray L.
McCulloch, Alan
Demmers, Pieter S.
Huebner, Claudia
Petermann, Ivonne
Han, Dug-Yeo
Ferguson, Lynnette R.
Gearry, Richard B.
Source
Gastroenterology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility.
Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response.
This study investigates the role that selected single nucleotide polymorphisms (SNPs) and haplotypes in the TNF-alpha receptor (TNSFRSF1B) gene play in the risk of IBD in a New Zealand Caucasian population.
DNA samples from 388 CD, 405 UC, 27 indeterminate colitis patients, and 293 randomly selected controls, from Canterbury, New Zealand were screened for 3 common SNPs in TNSFRSF1B: rs1061622 (c.676T>C), rs1061624 (c.∗1663A>G), and rs3397 (c.∗1690T>C), using TaqMan technologies.
Carrying the rs1061624 variant decreased the risk of UC in the left colon (OR 0.73, 95% CI=0.54–1.00) and of being a smoker at diagnosis (OR 0.62; 95% CI=0.40–0.96).
Carrying the rs3397 variant decreased the risk of penetrating CD (OR 0.62, 95% CI=0.40–0.95).
Three marker haplotype analyses revealed highly significant differences between CD patients and control subjects (χ2=29.9, df=7, P=.0001) and UC cases and controls (χ2=46.3, df=7, P<.0001).
We conclude that carrying a 3-marker haplotype in the TNSFRSF1B gene may increase (e.g., haplotype of GGC was 2.9-fold more in the CD or UCpatients) or decrease (e.g., TGT was 0.47-fold less in UC patients) the risk of IBD in a New Zealand Caucasian population.
American Psychological Association (APA)
Ferguson, Lynnette R.& Han, Dug-Yeo& Huebner, Claudia& Petermann, Ivonne& Barclay, Murray L.& Gearry, Richard B.…[et al.]. 2009. Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-483360
Modern Language Association (MLA)
Ferguson, Lynnette R.…[et al.]. Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population. Gastroenterology Research and Practice No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-483360
American Medical Association (AMA)
Ferguson, Lynnette R.& Han, Dug-Yeo& Huebner, Claudia& Petermann, Ivonne& Barclay, Murray L.& Gearry, Richard B.…[et al.]. Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-483360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483360