Hormonal and Sex Impact on the Epidemiology of Canine Lymphoma
Joint Authors
Tyler, Jeff W.
Villamil, J. Armando
Caldwell, Charles W.
Bryan, Jeffrey N.
Henry, Carolyn J.
Hahn, Allen W.
Source
Journal of Cancer Epidemiology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Surveillance Epidemiology and End Results data demonstrate that the risk of non-Hodgkin lymphoma is lower for women, but that the incidence increases after fifty years of age, at which menopause is regularly reached, suggesting that female hormones may be protective for NHL.
This study examines the influence of sex on lymphoma risk in a relevant large animal model.
Records for dogs in the Veterinary Medical Database were analyzed from 1964 to 2002.
Risk ratios were calculated to evaluate associations between sex, neutering status, and lymphoma occurrence.
A total of 14,573 cases and 1,157,342 controls were identified.
Intact females had a significantly lower risk of developing lymphoma, Odds Ratio 0.69 (0.63–0.74) with a P<.001.
We conclude that there is a sex effect on NHL risk in dogs similar to humans.
We hypothesize that the hormone levels of intact females lower the risk of NHL.
The possibility of a protective role of endogenous estrogens in the etiology of NHL should be investigated.
American Psychological Association (APA)
Villamil, J. Armando& Henry, Carolyn J.& Hahn, Allen W.& Bryan, Jeffrey N.& Tyler, Jeff W.& Caldwell, Charles W.. 2010. Hormonal and Sex Impact on the Epidemiology of Canine Lymphoma. Journal of Cancer Epidemiology،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-483363
Modern Language Association (MLA)
Villamil, J. Armando…[et al.]. Hormonal and Sex Impact on the Epidemiology of Canine Lymphoma. Journal of Cancer Epidemiology No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-483363
American Medical Association (AMA)
Villamil, J. Armando& Henry, Carolyn J.& Hahn, Allen W.& Bryan, Jeffrey N.& Tyler, Jeff W.& Caldwell, Charles W.. Hormonal and Sex Impact on the Epidemiology of Canine Lymphoma. Journal of Cancer Epidemiology. 2010. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-483363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483363