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Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients
Joint Authors
Bujanda, Luis
Chen, Chih-Chieh
Er, Tze-Kiong
Herreros-Villanueva, Marta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Targeting epidermal growth factor receptor (EGFR) has been one of the most effective colorectal cancer strategies.
Anti-EGFR antibodies function by binding to the extracellular domain of EGFR, preventing its activation, and ultimately providing clinical benefit.
KRAS mutations in codons 12 and 13 are recognized prognostic and predictive biomarkers that should be analyzed at the clinic prior to the administration of anti-EGFR therapy.
However, still an important fraction of KRAS wild-type patients do not respond to the treatment.
The identification of additional genetic determinants of primary or secondary resistance to EGFR targeted therapy for further improving the selection of patients is urgent.
Herein, we review the latest published literature highlighting the most important genes that may predict resistance to anti-EGFR monoclonal antibodies in colorectal cancer patients.
According to the available findings, the evaluation of BRAF, NRAS, PIK3CA, and PTEN status could be the right strategy to select patients who are likely to respond to anti-EGFR therapies.
In the future, the combination of those biomarkers will help establish consensus that can be introduced into clinical practice.
American Psychological Association (APA)
Er, Tze-Kiong& Chen, Chih-Chieh& Bujanda, Luis& Herreros-Villanueva, Marta. 2014. Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483376
Modern Language Association (MLA)
Er, Tze-Kiong…[et al.]. Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-483376
American Medical Association (AMA)
Er, Tze-Kiong& Chen, Chih-Chieh& Bujanda, Luis& Herreros-Villanueva, Marta. Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483376