Distribution of Myosin Attachment Times Predicted from Viscoelastic Mechanics of Striated Muscle
Joint Authors
Wang, Yuan
Palmer, Bradley M.
Miller, Mark S.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
We demonstrate that viscoelastic mechanics of striated muscle, measured as elastic and viscous moduli, emerge directly from the myosin crossbridge attachment time, tatt, also called time-on.
The distribution of tatt was modeled using a gamma distribution with shape parameter, p, and scale parameter, β.
At 5 mM MgATP, β was similar between mouse α-MyHC (16.0±3.7 ms) and β-MyHC (17.9±2.0 ms), and p was higher (P<0.05) for β-MyHC (5.6±0.4 no units) compared to α-MyHC (3.2±0.9).
At 1 mM MgATP, p approached a value of 10 in both isoforms, but β rose only in the β-MyHC (34.8±5.8 ms).
The estimated mean tatt (i.e., pβ product) was longer in the β-MyHC compared to α-MyHC, and became prolonged in both isoforms as MgATP was reduced as expected.
The application of our viscoelastic model to these isoforms and varying MgATP conditions suggest that tatt is better modeled as a gamma distribution due to its representing multiple temporal events occurring within tatt compared to a single exponential distribution which assumes only one temporal event within tatt.
American Psychological Association (APA)
Palmer, Bradley M.& Wang, Yuan& Miller, Mark S.. 2011. Distribution of Myosin Attachment Times Predicted from Viscoelastic Mechanics of Striated Muscle. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-483409
Modern Language Association (MLA)
Palmer, Bradley M.…[et al.]. Distribution of Myosin Attachment Times Predicted from Viscoelastic Mechanics of Striated Muscle. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-483409
American Medical Association (AMA)
Palmer, Bradley M.& Wang, Yuan& Miller, Mark S.. Distribution of Myosin Attachment Times Predicted from Viscoelastic Mechanics of Striated Muscle. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-483409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483409