Obesity, Visceral Fat, and NAFLD : Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathologic conditions ranging from steatosis alone to nonalcoholic steatohepatitis (NASH), with varying risks for progression to cirrhosis and hepatocellular carcinoma.
There is mounting evidence that NAFLD not only complicates obesity, but also perpetuates its metabolic consequences.
Critical event that leads to progressive liver injury in NAFLD is unknown.
Obesity reflects a generalized proinflammatory state with its increased inflammatory markers like C reactive protein, IL-6, IL-8, IL-10, PAI-1, TNF-α, and hepatocyte growth factor.
The elevated production of these adipokines is increasingly considered to be important in the development of diseases linked to obesity and the metabolic syndrome.
Disordered cytokine production is likely to play a role in the pathogenesis of NAFLD.
There is no effective treatment for NAFLD, though weight loss may halt disease progression and revert histological changes, the underlying mechanism remaining elusive.
All stages of the disease pathway from prevention, early identification/diagnosis, and treatment require an understanding of the pathogenesis of liver injury in NAFLD.
American Psychological Association (APA)
Mirza, M. S.. 2011. Obesity, Visceral Fat, and NAFLD : Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease. ISRN Gastroenterology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-483416
Modern Language Association (MLA)
Mirza, M. S.. Obesity, Visceral Fat, and NAFLD : Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease. ISRN Gastroenterology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-483416
American Medical Association (AMA)
Mirza, M. S.. Obesity, Visceral Fat, and NAFLD : Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease. ISRN Gastroenterology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-483416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483416