Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring : Evidence from Animal Models
Joint Authors
Vickers, Mark H.
Li, M.
Sloboda, Deborah M.
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence of obesity and overweight has reached epidemic proportions in the developed world as well as in those countries transitioning to first world economies, and this represents a major global health problem.
Concern is rising over the rapid increases in childhood obesity and metabolic disease that will translate into later adult obesity.
Although an obesogenic nutritional environment and increasingly sedentary lifestyle contribute to our risk of developing obesity, a growing body of evidence links early life nutritional adversity to the development of long-term metabolic disorders.
In particular, the increasing prevalence of maternal obesity and excess maternal weight gain has been associated with a heightened risk of obesity development in offspring in addition to an increased risk of pregnancy-related complications.
The mechanisms that link maternal obesity to obesity in offspring and the level of gene-environment interactions are not well understood, but the early life environment may represent a critical window for which intervention strategies could be developed to curb the current obesity epidemic.
This paper will discuss the various animal models of maternal overnutrition and their importance in our understanding of the mechanisms underlying altered obesity risk in offspring.
American Psychological Association (APA)
Li, M.& Sloboda, Deborah M.& Vickers, Mark H.. 2011. Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring : Evidence from Animal Models. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-483417
Modern Language Association (MLA)
Li, M.…[et al.]. Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring : Evidence from Animal Models. Experimental Diabetes Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-483417
American Medical Association (AMA)
Li, M.& Sloboda, Deborah M.& Vickers, Mark H.. Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring : Evidence from Animal Models. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-483417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483417