A Rare t(9;22;16)‎(q34;q11;q24)‎ Translocation in Chronic Myeloid Leukemia for Which Imatinib Mesylate Was Effective : A Case Report

Abstract EN

The t(9;22)(q34;q11) translocation is found in about 90% of chronic myeloid leukemia (CML) patients.

About 5–10% of CML patients have complex variant translocations involving a third chromosome in addition to chromosomes 9 and 22.

Herein, we describe a CML-chronic phase male with a complex translocation involving chromosome 16, t(9;22;16)(q34;q11;q24).

First, he was treated with interferon-alpha and intermittent hydroxyurea, but only a partial cytogenetic response was attained.

Subsequently, the patient was treated with imatinib mesylate because of an additional chromosome abnormality, trisomy 8.

A major molecular response was obtained after one year's imatinib therapy, and the follow-up chromosomal analysis performed 4 years and 3 months after the initiation of imatinib therapy displayed a normal karyotype of 46,XY.