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Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)
Joint Authors
Pinto, Rui
Teixeira, Frederico
Parada, Belmiro
Vala, Helena
Sereno, José
Mega, Cristina
Melo, Andreia
Rodrigues-Santos, Paulo
Pinto, Filipa
Nunes, Sara
Velada, Isabel
Garrido, Patrícia
Teixeira-de-Lemos, Edite
Reis, Flávio
Ferreira, Liliana
Fernandes, Rosa
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes.
Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10 mg/kg/bw).
Glucose, HbA1c, insulin, Total-c, TGs, IL-1β, TNF-α, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart.
Pancreatic histology was also evaluated.
Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1β.
Sitagliptin also showed a positive impact on lipid peroxidation and hypertension prevention.
In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities.
American Psychological Association (APA)
Ferreira, Liliana& Teixeira-de-Lemos, Edite& Pinto, Filipa& Parada, Belmiro& Mega, Cristina& Vala, Helena…[et al.]. 2010. Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat). Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-483455
Modern Language Association (MLA)
Ferreira, Liliana…[et al.]. Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat). Mediators of Inflammation No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-483455
American Medical Association (AMA)
Ferreira, Liliana& Teixeira-de-Lemos, Edite& Pinto, Filipa& Parada, Belmiro& Mega, Cristina& Vala, Helena…[et al.]. Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat). Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-483455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483455