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The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity : A Case Report
Joint Authors
van Vliet, Andre
Bruggeman, Richard
Abou Farha, Khalid
Knegtering, Henderikus
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Clozapine, an atypical antipsychotic, has proved to be superior to other antipsychotics in treating patients with refractory schizophrenia.
An increased plasma clozapine level above the therapeutic window may be associated with serious adverse events including paralytic ileus.
Clozapine toxicity may occur in association with infection or after drug overdose.
In a medical emergency situation, differentiating between a toxic clozapine ingestion and an infection-induced toxicity might be hindered by associated CNS changes and by the clozapine modulation of the inflammatory process.
This may delay prompt initiation of a tailored treatment strategy.
Here, we report a case of paralytic ileus developed within the context of clozapine toxicity.
Although the underlying cause of toxicity was not clinically obvious, giving antimicrobial therapy resulted in an improvement in the patient’s clinical condition.
This report indicates the value of serum levels of C-reactive protein and desmethylclozapine, major metabolite of clozapine, in the treatment of aetiologically unclear clozapine toxicity.
American Psychological Association (APA)
Abou Farha, Khalid& van Vliet, Andre& Knegtering, Henderikus& Bruggeman, Richard. 2012. The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity : A Case Report. Case Reports in Psychiatry،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-483456
Modern Language Association (MLA)
Abou Farha, Khalid…[et al.]. The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity : A Case Report. Case Reports in Psychiatry No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-483456
American Medical Association (AMA)
Abou Farha, Khalid& van Vliet, Andre& Knegtering, Henderikus& Bruggeman, Richard. The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity : A Case Report. Case Reports in Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-483456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483456