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Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats
Joint Authors
Ogai, Yuri O.
Kravchenko, Ganna B.
Krasilnikova, Oksana A.
Zagayko, Andriy L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver.
The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes.
We observed the age-dependent composition changes in HDL particle.
It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals.
In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group.
The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats.
Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats.
After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.
American Psychological Association (APA)
Zagayko, Andriy L.& Kravchenko, Ganna B.& Krasilnikova, Oksana A.& Ogai, Yuri O.. 2013. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-483570
Modern Language Association (MLA)
Zagayko, Andriy L.…[et al.]. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-483570
American Medical Association (AMA)
Zagayko, Andriy L.& Kravchenko, Ganna B.& Krasilnikova, Oksana A.& Ogai, Yuri O.. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-483570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483570