Energy and Redox Homeostasis in Tumor Cells
Joint Authors
Amôedo, Nivea Dias
de Oliveira, Marcus Fernandes
Rumjanek, Franklin David
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cancer cells display abnormal morphology, chromosomes, and metabolism.
This review will focus on the metabolism of tumor cells integrating the available data by way of a functional approach.
The first part contains a comprehensive introduction to bioenergetics, mitochondria, and the mechanisms of production and degradation of reactive oxygen species.
This will be followed by a discussion on the oxidative metabolism of tumor cells including the morphology, biogenesis, and networking of mitochondria.
Tumor cells overexpress proteins that favor fission, such as GTPase dynamin-related protein 1 (Drp1).
The interplay between proapoptotic members of the Bcl-2 family that promotes Drp 1-dependent mitochondrial fragmentation and fusogenic antiapoptotic proteins such as Opa-1 will be presented.
It will be argued that contrary to the widespread belief that in cancer cells, aerobic glycolysis completely replaces oxidative metabolism, a misrepresentation of Warburg’s original results, mitochondria of tumor cells are fully viable and functional.
Cancer cells also carry out oxidative metabolism and generally conform to the orthodox model of ATP production maintaining as well an intact electron transport system.
Finally, data will be presented indicating that the key to tumor cell survival in an ROS rich environment depends on the overexpression of antioxidant enzymes and high levels of the nonenzymatic antioxidant scavengers.
American Psychological Association (APA)
de Oliveira, Marcus Fernandes& Amôedo, Nivea Dias& Rumjanek, Franklin David. 2012. Energy and Redox Homeostasis in Tumor Cells. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-483574
Modern Language Association (MLA)
de Oliveira, Marcus Fernandes…[et al.]. Energy and Redox Homeostasis in Tumor Cells. International Journal of Cell Biology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-483574
American Medical Association (AMA)
de Oliveira, Marcus Fernandes& Amôedo, Nivea Dias& Rumjanek, Franklin David. Energy and Redox Homeostasis in Tumor Cells. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-483574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483574