The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief
Joint Authors
Milligan, Erin D.
Wilkerson, Jenny L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-11
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Under normal conditions, acute pain processing consists of well-characterized neuronal signaling events.
When dysfunctional pain signaling occurs, pathological pain ensues.
Glial activation and their released factors participate in the mediation of pathological pain.
The use of cannabinoid compounds for pain relief is currently an area of great interest for both basic scientists and physicians.
These compounds, bind mainly either the cannabinoid receptor subtype 1 (CB1R) or cannabinoid receptor subtype 2 (CB2R) and are able to modulate pain.
Although cannabinoids were initially only thought to modulate pain via neuronal mechanisms within the central nervous system, strong evidence now supports that CB2R cannabinoid compounds are capable of modulating glia, (e.g.
astrocytes and microglia) for pain relief.
However, the mechanisms underlying cannabinoid receptor-mediated pain relief remain largely unknown.
An emerging body of evidence supports that CB2R agonist compounds may prove to be powerful novel therapeutic candidates for the treatment of chronic pain.
American Psychological Association (APA)
Wilkerson, Jenny L.& Milligan, Erin D.. 2011. The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief. ISRN Anesthesiology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-483582
Modern Language Association (MLA)
Wilkerson, Jenny L.& Milligan, Erin D.. The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief. ISRN Anesthesiology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-483582
American Medical Association (AMA)
Wilkerson, Jenny L.& Milligan, Erin D.. The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief. ISRN Anesthesiology. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-483582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483582