Leptin : A Novel Therapeutic Target in Alzheimer's Disease?
Joint Authors
Beccano-Kelly, Dayne
Harvey, Jenni
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It is well established that the hormone leptin circulates in the plasma in amounts proportional to body fat content and it regulates food intake and body weight via its actions in the hypothalamus.
However, numerous studies have shown that leptin receptors are widely expressed throughout the CNS and evidence is growing that leptin plays a role in modulating a variety of neuronal processes.
In particular, recent studies have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of hippocampal synaptic function that are thought to underlie learning and memory processes including glutamate receptor trafficking, dendritic morphology, and activity-dependent synaptic plasticity.
Characterisation of the novel actions of leptin in limbic brain regions is providing valuable insights into leptin’s role in higher cognitive functions in health and disease.
American Psychological Association (APA)
Beccano-Kelly, Dayne& Harvey, Jenni. 2012. Leptin : A Novel Therapeutic Target in Alzheimer's Disease?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-483599
Modern Language Association (MLA)
Beccano-Kelly, Dayne& Harvey, Jenni. Leptin : A Novel Therapeutic Target in Alzheimer's Disease?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-483599
American Medical Association (AMA)
Beccano-Kelly, Dayne& Harvey, Jenni. Leptin : A Novel Therapeutic Target in Alzheimer's Disease?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-483599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483599