The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus
Joint Authors
Derkach, Kira V.
Shpakov, Alexander O.
Source
Journal of Signal Transduction
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Diabetes mellitus (DM) induces a large number of diseases of the nervous, cardiovascular, and some other systems of the organism.
One of the main causes of the diseases is the changes in the functional activity of hormonal signaling systems which lead to the alterations and abnormalities of the cellular processes and contribute to triggering and developing many DM complications.
The key role in the control of physiological and biochemical processes belongs to the adenylyl cyclase (AC) signaling system, sensitive to biogenic amines and polypeptide hormones.
The review is devoted to the changes in the GPCR-G protein-AC system in the brain, heart, skeletal muscles, liver, and the adipose tissue in experimental and human DM of the types 1 and 2 and also to the role of the changes in AC signaling in the pathogenesis and etiology of DM and its complications.
It is shown that the changes of the functional state of hormone-sensitive AC system are dependent to a large extent on the type and duration of DM and in experimental DM on the model of the disease.
The degree of alterations and abnormalities of AC signaling pathways correlates very well with the severity of DM and its complications.
American Psychological Association (APA)
Shpakov, Alexander O.& Derkach, Kira V.. 2013. The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus. Journal of Signal Transduction،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-483603
Modern Language Association (MLA)
Shpakov, Alexander O.& Derkach, Kira V.. The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus. Journal of Signal Transduction No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-483603
American Medical Association (AMA)
Shpakov, Alexander O.& Derkach, Kira V.. The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus. Journal of Signal Transduction. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-483603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483603