Characterization of the Antibiotic Compound No. 70 Produced by Streptomyces sp. IMV-70
Joint Authors
Katrukha, Genrikh S.
Tokareva, Nina L.
Khasenova, Almagul K.
Azizan, Azliyati
Kwa, Boo H.
Fedorova, Galina B.
Balgimbaeva, Assya S.
Trenozhnikova, Lyudmila P.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity.
After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified as Streptomyces sp.
IMV-70.
In the process of fermentation, the strain Streptomyces spp.
IMV-70 produces the antibiotic no.
70, which was isolated from the culture broth by extraction with organic solvents.
Antibiotic compound no.
70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods.
The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A.
Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics.
The physical-chemical and biological characteristics of these preparations were described and further researched.
Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no.
70 enable us to research further the potential of this new class of antibiotics.
American Psychological Association (APA)
Trenozhnikova, Lyudmila P.& Khasenova, Almagul K.& Balgimbaeva, Assya S.& Fedorova, Galina B.& Katrukha, Genrikh S.& Tokareva, Nina L.…[et al.]. 2012. Characterization of the Antibiotic Compound No. 70 Produced by Streptomyces sp. IMV-70. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483606
Modern Language Association (MLA)
Trenozhnikova, Lyudmila P.…[et al.]. Characterization of the Antibiotic Compound No. 70 Produced by Streptomyces sp. IMV-70. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-483606
American Medical Association (AMA)
Trenozhnikova, Lyudmila P.& Khasenova, Almagul K.& Balgimbaeva, Assya S.& Fedorova, Galina B.& Katrukha, Genrikh S.& Tokareva, Nina L.…[et al.]. Characterization of the Antibiotic Compound No. 70 Produced by Streptomyces sp. IMV-70. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483606