Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives
Joint Authors
Brossmer, Reinchard
Bovin, Nicolai
Pazynina, Galina
Tuzikov, Alexander
Nasonov, Vitaly
Maisel, Maxim
Belyanchikov, Ivan
Source
International Journal of Carbohydrate Chemistry
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Earlier we reported a convenient and efficient method of preparing α2-6 sialooligosaccharides in conditions of Koenigs-Knorr reaction.
The use of Ag2CO3 allowed carrying out α2-6 sialylation of galacto-4,6-diol of mono- and disaccharides with chloride of acetylated N-acetylneuraminic acid methyl ester as glycosyl donor.
In this study we applied this approach to other derivatives of neuraminic acid, namely, Neu5Gc, 9-deoxy-9-NAc-Neu5Ac, Neu5Acα2-8Neu5Ac, and Neu5Acα2-8Neu5Acα2-8Neu5Ac as glycosyl donors; eight compounds were synthesized: Neu5Gcα-O(CH2)3NH2 (8), Neu5Gcα2-6Galβ1-4GlcNAcβ-O(CH2)3NH2 (10), 9-deoxy-9-NAc-Neu5Ac-O(CH2)3NH2 (15), 9-deoxy-9-NAc-Neu5Acα2-6Galβ1-4GlcNAcβ-O(CH2)3NH2 (17), Neu5Acα2-8Neu5Acα-O(CH2)3NH2(23) Neu5Acα2-8Neu5Acα-OCH3 (24), Neu5Acα2-8Neu5Acα-OCH2(p-C6H4)NHCOCH2NH2 (25), and Neu5Acα2-8Neu5Acα2-8Neu5Acα-O(CH2)3NH2 (32).
These sialosides were used for characterization of siglecs and other carbohydrate-binding proteins.
American Psychological Association (APA)
Pazynina, Galina& Nasonov, Vitaly& Belyanchikov, Ivan& Brossmer, Reinchard& Maisel, Maxim& Tuzikov, Alexander…[et al.]. 2010. Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives. International Journal of Carbohydrate Chemistry،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-483609
Modern Language Association (MLA)
Pazynina, Galina…[et al.]. Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives. International Journal of Carbohydrate Chemistry No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-483609
American Medical Association (AMA)
Pazynina, Galina& Nasonov, Vitaly& Belyanchikov, Ivan& Brossmer, Reinchard& Maisel, Maxim& Tuzikov, Alexander…[et al.]. Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives. International Journal of Carbohydrate Chemistry. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-483609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483609
