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Protective Role of the ACE2Ang-(1–9) Axis in Cardiovascular Remodeling
Joint Authors
Jalil, Jorge E.
Ocaranza, María Paz
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Despite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world.
Pharmacological therapies based on the renin angiotensin system (RAS) blockade are used extensively for the treatment of hypertension, heart failure, and CV remodeling but in spite of their success the prevalence of end-organ damage and residual risk remain still high.
Novel approaches must be discovered for a more effective treatment of residual CV remodeling and risk.
The ACE2/Ang-(1–9) axis is a new and important target to counterbalance the vasoconstrictive/proliferative RAS axis.
Ang-(1–9) is hydrolyzed slower than Ang-(1–7) and is able to bind the Ang II type 2 receptor.
We review here the current experimental evidence suggesting that activation of the ACE2/Ang-(1–9) axis protects the heart and vessels (and possibly the kidney) from adverse cardiovascular remodeling in hypertension as well as in heart failure.
American Psychological Association (APA)
Ocaranza, María Paz& Jalil, Jorge E.. 2012. Protective Role of the ACE2Ang-(1–9) Axis in Cardiovascular Remodeling. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-483621
Modern Language Association (MLA)
Ocaranza, María Paz& Jalil, Jorge E.. Protective Role of the ACE2Ang-(1–9) Axis in Cardiovascular Remodeling. International Journal of Hypertension No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-483621
American Medical Association (AMA)
Ocaranza, María Paz& Jalil, Jorge E.. Protective Role of the ACE2Ang-(1–9) Axis in Cardiovascular Remodeling. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-483621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483621