Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma
Joint Authors
Avdalyan, Ashot
Klimachev, Vladimir
Lazarev, Alexander
Bobrov, Igor
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The objective of this study was to investigate the prognostic value of microvessel density (MVD) in uterine leiomyosarcoma (LMS) and peritumoral area (PA) as evaluated by CD31 expression and argyrophilic nucleolar organizer region (AgNOR) count in endothelial cells.
Tissue specimens from 66 patients with uterine LMS were examined.
There were no significant differences in the mean MVD between tumor itself and the PA (P=0.9); moreover, the MVD in the PA often exceeded that in the tumor.
No correlation or significant differences were also found in the MVD between different grades of malignancy of LMS (r=0.1; P=0.07).
The number of AgNORs in tumor endothelial cells was significantly higher in tumor vessels than in the peritumoral area (P<0.005) and increased with the tumor grade.
Analysis of the prognostic value of MVD in uterine LMS and PA showed that the density of tumor vessels was not an independent criterion, while the MVD in the PA affected 10-year survival to a significantly greater extent (χ2=27.5; P=0.0003).
The number of AgNORs also had an important effect on survival of LMS patients: when the threshold of 11.6 granules was exceeded, prognosis was significantly more unfavorable than that prior to exceeding the threshold.
American Psychological Association (APA)
Avdalyan, Ashot& Bobrov, Igor& Klimachev, Vladimir& Lazarev, Alexander. 2012. Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma. Sarcoma،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483630
Modern Language Association (MLA)
Avdalyan, Ashot…[et al.]. Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma. Sarcoma No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-483630
American Medical Association (AMA)
Avdalyan, Ashot& Bobrov, Igor& Klimachev, Vladimir& Lazarev, Alexander. Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483630