Cisplatin and Short-Term 5-Fluorouracil Infusion for Paraneoplastic Microangiopathic Hemolytic Anemia in Gastric Cancer : A Case Report and Review of the Literature
Joint Authors
Lazo-Langner, Alejandro
al-Rasheedy, I. M.
Sanatani, M. S.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Microangiopathic hemolytic anemia is a rare paraneoplastic syndrome accompanying adenocarcinoma of the stomach.
We report on a patient presenting with anemia due to a combination of severe hemolysis and tumour bleeding, where the combination of cisplatin and 5-fluorouracil in a short course infusional regimen led to a complete response of the hematologic abnormalities in the first line setting.
Relapse was successfully treated with second line docetaxel; however the response was relatively short-lived.
Overall survival was 16 months from diagnosis, which compares favourably to the survival of other reported cases.
The chemotherapy regimens used in previously reported similar cases are reviewed.
We suggest that a regimen based on bolus 5-fluorouracil, possibly with a platinum, should be investigated as a possible regimen of choice.
American Psychological Association (APA)
Sanatani, M. S.& Lazo-Langner, Alejandro& al-Rasheedy, I. M.. 2013. Cisplatin and Short-Term 5-Fluorouracil Infusion for Paraneoplastic Microangiopathic Hemolytic Anemia in Gastric Cancer : A Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-483656
Modern Language Association (MLA)
Sanatani, M. S.…[et al.]. Cisplatin and Short-Term 5-Fluorouracil Infusion for Paraneoplastic Microangiopathic Hemolytic Anemia in Gastric Cancer : A Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-483656
American Medical Association (AMA)
Sanatani, M. S.& Lazo-Langner, Alejandro& al-Rasheedy, I. M.. Cisplatin and Short-Term 5-Fluorouracil Infusion for Paraneoplastic Microangiopathic Hemolytic Anemia in Gastric Cancer : A Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-483656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483656