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The Role of Cytokine in the Lupus Nephritis
Joint Authors
Iwata, Yasunori
Kaneko, Shuichi
Wada, Takashi
Furuichi, Kengo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lupus nephritis (LN) is a major clinical manifestation of systemic lupus erythematosus (SLE).
Although numerous abnormalities of immune system have been proposed, cytokine overexpression plays an essential role in the pathogenesis of LN.
In the initial phase of the disease, the immune deposits and/or autoantibodies induce cytokine production in renal resident cells, leading to further inflammatory cytokine/chemokine expression and leukocyte infiltration and activation.
Then, infiltrate leukocytes, such as macrophages (Mφ) and dendritic cells (DCs), secrete a variety of cytokines and activate naïve T cells, leading the cytokine profile towards T helper (Th)1, Th2, and/or Th17.
Recent studies revealed these inflammatory processes in experimental animal models as well as human LN.
The cytokine targeted intervention may have the therapeutic potentials for LN.
This paper focuses on the expression of cytokine and its functional role in the pathogenesis of LN.
American Psychological Association (APA)
Iwata, Yasunori& Furuichi, Kengo& Kaneko, Shuichi& Wada, Takashi. 2011. The Role of Cytokine in the Lupus Nephritis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-483659
Modern Language Association (MLA)
Iwata, Yasunori…[et al.]. The Role of Cytokine in the Lupus Nephritis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-483659
American Medical Association (AMA)
Iwata, Yasunori& Furuichi, Kengo& Kaneko, Shuichi& Wada, Takashi. The Role of Cytokine in the Lupus Nephritis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-483659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483659