Improving Islet Engraftment by Gene Therapy
Joint Authors
Wang, Xiaojie
Verchere, C. Bruce
Mui, Alice
Warnock, Garth L.
Ou, Dawei
Meloche, Mark
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes.
However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients, and impaired hormone modulation in the local transplanted site.
Strategies using genetic modification methods through overexpression or silencing of those proteins involved in promoting new formation of blood vessels or inhibition of apoptosis may overcome these hurdles and improve islet engraftment outcomes.
American Psychological Association (APA)
Wang, Xiaojie& Meloche, Mark& Verchere, C. Bruce& Ou, Dawei& Mui, Alice& Warnock, Garth L.. 2011. Improving Islet Engraftment by Gene Therapy. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-483663
Modern Language Association (MLA)
Wang, Xiaojie…[et al.]. Improving Islet Engraftment by Gene Therapy. Journal of Transplantation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-483663
American Medical Association (AMA)
Wang, Xiaojie& Meloche, Mark& Verchere, C. Bruce& Ou, Dawei& Mui, Alice& Warnock, Garth L.. Improving Islet Engraftment by Gene Therapy. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-483663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483663