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Preclinical Evidence for the Benefits of Penile Rehabilitation Therapy following Nerve-Sparing Radical Prostatectomy
Joint Authors
Albersen, M.
Joniau, Steven
Van Poppel, Hendrik
Claes, H.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques.
This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional veno-occlusive dysfunction.
Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clinically studied for treatment of postprostatectomy erectile dysfunction.
Since these studies showed benefits of “penile rehabilitation therapy,” these effects have been studied in a preclinical setting.
We reviewed experimental literature on erectile tissue preserving and neuroregenerative treatment strategies, and found that preservation of the erectile tissue by the use of intracavernous nitric oxide donors or vasoactive substances, oral PDE5-inhibitors, and hyperbaric oxygen therapy improved erectile function by antifibrotic effects and preservation of smooth muscle.
Furthermore, neuroregenerative strategies using neuroimmunophilin ligands, neurotrophins, growth factors, and stem cell therapy show improved erectile function by preservation of NOS-containing nerve fibers.
American Psychological Association (APA)
Albersen, M.& Joniau, Steven& Claes, H.& Van Poppel, Hendrik. 2008. Preclinical Evidence for the Benefits of Penile Rehabilitation Therapy following Nerve-Sparing Radical Prostatectomy. Advances in Urology،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-483667
Modern Language Association (MLA)
Albersen, M.…[et al.]. Preclinical Evidence for the Benefits of Penile Rehabilitation Therapy following Nerve-Sparing Radical Prostatectomy. Advances in Urology No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-483667
American Medical Association (AMA)
Albersen, M.& Joniau, Steven& Claes, H.& Van Poppel, Hendrik. Preclinical Evidence for the Benefits of Penile Rehabilitation Therapy following Nerve-Sparing Radical Prostatectomy. Advances in Urology. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-483667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483667