Targeting Herpetic Keratitis by Gene Therapy
Joint Authors
Elbadawy, Hossein Mostafa
Gailledrat, Marine
Ferrari, Stefano
Desseaux, Carole
Ponzin, Diego
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Ocular gene therapy is rapidly becoming a reality.
By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents.
Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause serious complications that may lead to blindness.
Recurrence of the disease is likely and cornea transplantation, therefore, might not be the ideal therapeutic solution.
This paper will focus on the current situation of ocular gene therapy research against herpetic keratitis, including the use of viral and nonviral vectors, routes of delivery of therapeutic genes, new techniques, and key research strategies.
Whereas the correction of inherited diseases was the initial goal of the field of gene therapy, here we discuss transgene expression, gene replacement, silencing, or clipping.
Gene therapy of herpetic keratitis previously reported in the literature is screened emphasizing candidate gene therapy targets.
Commonly adopted strategies are discussed to assess the relative advantages of the protective therapy using antiviral drugs and the common gene therapy against long-term HSV-1 ocular infections signs, inflammation and neovascularization.
Successful gene therapy can provide innovative physiological and pharmaceutical solutions against herpetic keratitis.
American Psychological Association (APA)
Elbadawy, Hossein Mostafa& Gailledrat, Marine& Desseaux, Carole& Ponzin, Diego& Ferrari, Stefano. 2012. Targeting Herpetic Keratitis by Gene Therapy. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-483668
Modern Language Association (MLA)
Elbadawy, Hossein Mostafa…[et al.]. Targeting Herpetic Keratitis by Gene Therapy. Journal of Ophthalmology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-483668
American Medical Association (AMA)
Elbadawy, Hossein Mostafa& Gailledrat, Marine& Desseaux, Carole& Ponzin, Diego& Ferrari, Stefano. Targeting Herpetic Keratitis by Gene Therapy. Journal of Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-483668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483668