Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II
Joint Authors
Kucukislamoglu, Mustafa
Gençer, Nahit
Sonmez, Fatih
Kuday, Hilal
Bilen, Cigdem
Yavuz, Emre
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d]pyrimidine derivatives on purified human carbonic anhydrase I and II (hCA I and II) were investigated by using CO2 as a substrate.
The results showed that all compounds inhibited the hCA I and hCA II enzyme activities.
Among all the synthesized compounds, 7e (IC50=6.79 µM) was found to be the most active compound for hCA I inhibitory activity and 5g (IC50=7.22 µM) showed the highest hCA II inhibitory activity.
Structure-activity relationships study showed that indolylchalcone derivatives have higher inhibitory activities than pyrido[2,3-d]pyrimidine derivatives on hCA I and hCA II.
Additionally, methyl group bonded to uracil ring increases inhibitory activities on both hCA I and hCA II.
American Psychological Association (APA)
Kuday, Hilal& Sonmez, Fatih& Bilen, Cigdem& Yavuz, Emre& Gençer, Nahit& Kucukislamoglu, Mustafa. 2014. Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483670
Modern Language Association (MLA)
Kuday, Hilal…[et al.]. Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-483670
American Medical Association (AMA)
Kuday, Hilal& Sonmez, Fatih& Bilen, Cigdem& Yavuz, Emre& Gençer, Nahit& Kucukislamoglu, Mustafa. Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483670
