Factor V Leiden and Inflammation
Joint Authors
Perez-Pujol, Silvia
Aras, Omer
Escolar, Ginés
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state.
Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state.
Less attention has been paid about the possible role of FVL in inflammatory conditions known to be present in different disorders such as uremia, cirrhosis, liver transplantation, depression as well as sepsis, infection or, inflammatory bowel disease (IBD).
Whether platelet FVL will increase the activation of coagulation and/or in which proportion is able to determine the final outcome in the previously mentioned inflammatory conditions is a subject that remains uncertain.
This paper will review the association of FVL with inflammation.
Specifically, it will analyze the important role of the endothelium and the contribution of other inflammatory components involved at both the immune and vascular levels.
This paper will also try to emphasize the importance of being a FVL carrier in associations to diseases where a chronic inflammation occurs, and how this condition may be determinant in the progression and outcome of a specific clinic situation.
American Psychological Association (APA)
Perez-Pujol, Silvia& Aras, Omer& Escolar, Ginés. 2012. Factor V Leiden and Inflammation. Thrombosis،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483679
Modern Language Association (MLA)
Perez-Pujol, Silvia…[et al.]. Factor V Leiden and Inflammation. Thrombosis No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483679
American Medical Association (AMA)
Perez-Pujol, Silvia& Aras, Omer& Escolar, Ginés. Factor V Leiden and Inflammation. Thrombosis. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483679