Autophagy : Friend or Foe in Breast Cancer Development, Progression, and Treatment
Joint Authors
Berardi, Damian E.
Campodónico, Paola B.
Todaro, Laura B.
Urtreger, Alejandro J.
Díaz Bessone, Maria Ines
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes.
This degradative pathway sustains cell survival during nutrient deprivation, but in some circumstances, autophagy leads to cell death.
Thereby, autophagy can serve as tumor suppressor, as the reduction in autophagic capacity causes malignant transformation and spontaneous tumors.
On the other hand, this process also functions as a protective cell-survival mechanism against environmental stress causing resistance to antineoplastic therapies.
Although autophagy inhibition, combined with anticancer agents, could be therapeutically beneficial in some cases, autophagy induction by itself could lead to cell death in some apoptosis-resistant cancers, indicating that autophagy induction may also be used as a therapy.
This paper summarizes the most important findings described in the literature about autophagy and also discusses the importance of this process in clinical settings.
American Psychological Association (APA)
Berardi, Damian E.& Campodónico, Paola B.& Díaz Bessone, Maria Ines& Urtreger, Alejandro J.& Todaro, Laura B.. 2011. Autophagy : Friend or Foe in Breast Cancer Development, Progression, and Treatment. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-483687
Modern Language Association (MLA)
Berardi, Damian E.…[et al.]. Autophagy : Friend or Foe in Breast Cancer Development, Progression, and Treatment. International Journal of Breast Cancer No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-483687
American Medical Association (AMA)
Berardi, Damian E.& Campodónico, Paola B.& Díaz Bessone, Maria Ines& Urtreger, Alejandro J.& Todaro, Laura B.. Autophagy : Friend or Foe in Breast Cancer Development, Progression, and Treatment. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-483687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483687