Chitosan-Alginate Sponge : Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat
Joint Authors
Wei, Yu Quan
Qian, Zhiyong
Zheng, XiuLing
Luo, Feng
Guo, Gang
Xu, Xu
Kong, XiangYe
Dai, Mei
Li, XingYi
Zhao, Xia
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work.
The sponge was ethereal and pliable.
The chemical structure and morphology of the sponges was characterized by FTIR and SEM.
The swelling ability, in vitro drug release and degradation behaviors, and an in vivo animal test were employed to confirm the applicability of this sponge as a wound dressing material.
As the chitosan content in the sponge decreased, the swelling ability decreased.
All types of the sponges exhibited biodegradable properties.
The release of curcumin from the sponges could be controlled by the crosslinking degree.
Curcumin could be released from the sponges in an extended period for up to 20 days.
An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect.
American Psychological Association (APA)
Dai, Mei& Zheng, XiuLing& Xu, Xu& Kong, XiangYe& Li, XingYi& Guo, Gang…[et al.]. 2009. Chitosan-Alginate Sponge : Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-483690
Modern Language Association (MLA)
Dai, Mei…[et al.]. Chitosan-Alginate Sponge : Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-483690
American Medical Association (AMA)
Dai, Mei& Zheng, XiuLing& Xu, Xu& Kong, XiangYe& Li, XingYi& Guo, Gang…[et al.]. Chitosan-Alginate Sponge : Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-483690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483690