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The Role of the Entorhinal Cortex in Extinction : Influences of Aging
Joint Authors
Izquierdo, Iván
Bonini, Juliana S.
Medina, Jorge H.
Monteiro, Siomara
Myskiw, Jociane C.
Rossato, Janine I.
Bevilaqua, Lia R. M.
Cammarota, Martín
Lima, Ramón H.
Clarke, Julia R.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease.
It plays a key role in memory formation, retrieval, and extinction, as part of circuits that include the hippocampus, the amygdaloid nucleus, and several regions of the neocortex, in particular of the prefrontal cortex.
Lesions or biochemical impairments of the entorhinal cortex hinder extinction.
Microinfusion experiments have shown that glutamate NMDA receptors, calcium and calmodulin-dependent protein kinase II, and protein synthesis in the entorhinal cortex are involved in and required for extinction.
Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex.
American Psychological Association (APA)
Bevilaqua, Lia R. M.& Rossato, Janine I.& Bonini, Juliana S.& Myskiw, Jociane C.& Clarke, Julia R.& Monteiro, Siomara…[et al.]. 2008. The Role of the Entorhinal Cortex in Extinction : Influences of Aging. Neural Plasticity،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-483701
Modern Language Association (MLA)
Bevilaqua, Lia R. M.…[et al.]. The Role of the Entorhinal Cortex in Extinction : Influences of Aging. Neural Plasticity No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-483701
American Medical Association (AMA)
Bevilaqua, Lia R. M.& Rossato, Janine I.& Bonini, Juliana S.& Myskiw, Jociane C.& Clarke, Julia R.& Monteiro, Siomara…[et al.]. The Role of the Entorhinal Cortex in Extinction : Influences of Aging. Neural Plasticity. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-483701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483701