Nutritional Manipulation of One-Carbon Metabolism : Effects on Arsenic Methylation and Toxicity
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Exposure to arsenic (As) through drinking water is a substantial problem worldwide.
The methylation of As, a reactive metalloid, generates monomethyl- (MMA) and dimethyl-arsenical (DMA) species.
The biochemical pathway that catalyzes these reactions, one-carbon metabolism, is regulated by folate and other micronutrients.
Arsenic methylation exerts a critical influence on both its urinary elimination and chemical reactivity.
Mice having the As methyltransferase null genotype show reduced urinary As excretion, increased As retention, and severe systemic toxicity.
The most toxic As metabolite in vitro is MMAIII, an intermediate in the generation of DMAV, a much less toxic metabolite.
These findings have raised the question of whether As methylation is a detoxification or bioactivation pathway.
Results of population-based studies suggest that complete methylation of inorganic As to DMA is associated with reduced risk for As-induced health outcomes, and that nutrients involved in one-carbon metabolism, such as folate, can facilitate As methylation and elimination.
American Psychological Association (APA)
Hall, Megan N.& Gamble, Mary V.. 2012. Nutritional Manipulation of One-Carbon Metabolism : Effects on Arsenic Methylation and Toxicity. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483707
Modern Language Association (MLA)
Hall, Megan N.& Gamble, Mary V.. Nutritional Manipulation of One-Carbon Metabolism : Effects on Arsenic Methylation and Toxicity. Journal of Toxicology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-483707
American Medical Association (AMA)
Hall, Megan N.& Gamble, Mary V.. Nutritional Manipulation of One-Carbon Metabolism : Effects on Arsenic Methylation and Toxicity. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483707