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Gene Regulation Systems for Gene Therapy Applications in the Central Nervous System
Joint Authors
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Substantial progress has been made in the development of novel gene therapy strategies for central nervous system (CNS) disorders in recent years.
However, unregulated transgene expression is a significant issue limiting human applications due to the potential side effects from excessive levels of transgenic protein that indiscriminately affect both diseased and nondiseased cells.
Gene regulation systems are a tool by which tight tissue-specific and temporal regulation of transgene expression may be achieved.
This review covers the features of ideal regulatory systems and summarises the mechanics of current exogenous and endogenous gene regulation systems and their utility in the CNS.
American Psychological Association (APA)
Naidoo, Jerusha& Young, Deborah. 2012. Gene Regulation Systems for Gene Therapy Applications in the Central Nervous System. Neurology Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483718
Modern Language Association (MLA)
Naidoo, Jerusha& Young, Deborah. Gene Regulation Systems for Gene Therapy Applications in the Central Nervous System. Neurology Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483718
American Medical Association (AMA)
Naidoo, Jerusha& Young, Deborah. Gene Regulation Systems for Gene Therapy Applications in the Central Nervous System. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483718