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Current Concepts on Antiplatelet Therapy : Focus on the Novel Thienopyridine and Non-Thienopyridine Agents
Joint Authors
Latini, R. A.
Pizzocri, S.
Valgimigli, M.
Bhindi, R.
Ward, M. R.
Brambilla, N.
Lanotte, S.
Figtree, G. A.
Laudisa, M. L.
Testa, L.
Biondi Zoccai, G. G. L.
Bedogni, F.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thienopyridines are a class of drug targeting the platelet adenosine diphosphate (ADP) 2 receptor.
They significantly reduce platelet activity and are therefore clinically beneficial in settings where platelet activation is a key pathophysiological feature, particularly myocardial infarction.
Ticlopidine, the first of the class introduced to clinical practice, was soon challenged and almost completely replaced by clopidogrel for its better tolerability.
More recently, prasugrel and ticagrelor have been shown to provide a more powerful antiplatelet action compared to clopidogrel but at a cost of higher risk of bleeding complications.
Cangrelor, a molecule very similar to ticagrelor, is currently being evaluated against clopidogrel.
Considering the key balance of ischemic protection and bleeding risk, this paper discusses the background to the development of prasugrel, ticagrelor, and cangrelor and aims to characterise their risk-benefit profile and possible implementation in daily practice.
American Psychological Association (APA)
Testa, L.& Biondi Zoccai, G. G. L.& Valgimigli, M.& Latini, R. A.& Pizzocri, S.& Lanotte, S.…[et al.]. 2010. Current Concepts on Antiplatelet Therapy : Focus on the Novel Thienopyridine and Non-Thienopyridine Agents. Advances in Hematology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-483754
Modern Language Association (MLA)
Testa, L.…[et al.]. Current Concepts on Antiplatelet Therapy : Focus on the Novel Thienopyridine and Non-Thienopyridine Agents. Advances in Hematology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-483754
American Medical Association (AMA)
Testa, L.& Biondi Zoccai, G. G. L.& Valgimigli, M.& Latini, R. A.& Pizzocri, S.& Lanotte, S.…[et al.]. Current Concepts on Antiplatelet Therapy : Focus on the Novel Thienopyridine and Non-Thienopyridine Agents. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-483754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483754