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Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies
Joint Authors
Banerji, Versha
Gibson, Spencer B.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Autophagy is a cellular process that maintains the homeostasis of the normal cell.
It not only allows for cell survival in times of metabolic stress with nutrient recycling but also is able to lead to cell death when required.
During malignant transformation the cell is able to proliferate and survive.
This is due to altered cell metabolism and the presence of altered genetic changes that maintain the cell survival.
Metabolism was considered an innocent bystander that was a consequence of the increased nutrient requirement for the survival and proliferation of haematological malignancies.
The interdependency of metabolism and cellular mechanisms such as autophagy are becoming more evident and important.
This interdependence contributes to increased cancer progression and drug resistance.
In this paper we aim to discuss autophagy, how it pertains to metabolism in the context of hematologic malignancies, and the implications for therapy.
American Psychological Association (APA)
Banerji, Versha& Gibson, Spencer B.. 2012. Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-483760
Modern Language Association (MLA)
Banerji, Versha& Gibson, Spencer B.. Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies. International Journal of Cell Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-483760
American Medical Association (AMA)
Banerji, Versha& Gibson, Spencer B.. Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-483760
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483760