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Periodontal Pathogens and Atherosclerosis : Implications of Inflammation and Oxidative Modification of LDL
Joint Authors
Yamamoto, Masafumi
Kurita-Ochiai, Tomoko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation is well accepted to play a crucial role in the development of atherosclerotic lesions, and recent studies have demonstrated an association between periodontal disease and cardiovascular disease.
Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, causative agents of destructive chronic inflammation in the periodontium, can accelerate atheroma deposition in animal models.
Emerging evidence suggests that vaccination against virulence factors of these pathogens and anti-inflammatory therapy may confer disease resistance.
In this review, we focus on the role of inflammatory mechanisms and oxidative modification in the formation and activation of atherosclerotic plaques accelerated by P.
gingivalis or A.
actinomycetemcomitans in an ApoE-deficient mouse model and high-fat-diet-fed mice.
Furthermore, we examine whether mucosal vaccination with a periodontal pathogen or the anti-inflammatory activity of catechins can reduce periodontal pathogen-accelerated atherosclerosis.
American Psychological Association (APA)
Kurita-Ochiai, Tomoko& Yamamoto, Masafumi. 2014. Periodontal Pathogens and Atherosclerosis : Implications of Inflammation and Oxidative Modification of LDL. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-483761
Modern Language Association (MLA)
Kurita-Ochiai, Tomoko& Yamamoto, Masafumi. Periodontal Pathogens and Atherosclerosis : Implications of Inflammation and Oxidative Modification of LDL. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-483761
American Medical Association (AMA)
Kurita-Ochiai, Tomoko& Yamamoto, Masafumi. Periodontal Pathogens and Atherosclerosis : Implications of Inflammation and Oxidative Modification of LDL. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-483761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483761