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Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Intestinal epithelial barrier plays a critical role in the maintenance of gut homeostasis by limiting the penetration of luminal bacteria and dietary allergens, yet allowing antigen sampling for the generation of tolerance.
Undigested proteins normally do not gain access to the lamina propria due to physical exclusion by tight junctions at the cell-cell contact sites and intracellular degradation by lysosomal enzymes in enterocytes.
An intriguing question then arises: how do macromolecular food antigens cross the epithelial barrier? This review discusses the epithelial barrier dysfunction in sensitized intestine with special emphasis on the molecular mechanism of the enhanced transcytotic rates of allergens.
The sensitization phase of allergy is characterized by antigen-induced cross-linking of IgE bound to high affinity FcεRI on mast cell surface, leading to anaphylactic responses.
Recent studies have demonstrated that prior to mast cell activation, food allergens are transported in large quantity across the epithelium and are protected from lysosomal degradation by binding to cell surface IgE and low-affinity receptor CD23/FcεRII.
Improved immunotherapies are currently under study including anti-IgE and anti-CD23 antibodies for the management of atopic disorders.
American Psychological Association (APA)
Yu, Linda Chia-Hui. 2011. Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity. Journal of Allergy،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483771
Modern Language Association (MLA)
Yu, Linda Chia-Hui. Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity. Journal of Allergy No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-483771
American Medical Association (AMA)
Yu, Linda Chia-Hui. Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity. Journal of Allergy. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483771