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Supplemental Cellular Protection by a Carotenoid Extends Lifespan via InsIGF-1 Signaling in Caenorhabditis elegans
Joint Authors
Oshiro, Satoru
Yazaki, Koumei
Yoshikoshi, Chinatsu
Yanase, Sumino
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Astaxanthin (AX), which is produced by some marine animals, is a type of carotenoid that has antioxidative properties.
In this study, we initially examined the effects of AX on the aging of a model organism C.
elegans that has the conserved intracellular pathways related to mammalian longevity.
The continuous treatments with AX (0.1 to 1 mM) from both the prereproductive and young adult stages extended the mean lifespans by about 16–30% in the wild-type and long-lived mutant age-1 of C.
elegans.
In contrast, the AX-dependent lifespan extension was not observed even in a daf-16 null mutant.
Especially, the expression of genes encoding superoxide dismutases and catalases increased in two weeks after hatching, and the DAF-16 protein was translocated to the nucleus in the AX-exposed wild type.
These results suggest that AX protects the cell organelle mitochondria and nucleus of the nematode, resulting in a lifespan extension via an Ins/IGF-1 signaling pathway during normal aging, at least in part.
American Psychological Association (APA)
Yazaki, Koumei& Yoshikoshi, Chinatsu& Oshiro, Satoru& Yanase, Sumino. 2011. Supplemental Cellular Protection by a Carotenoid Extends Lifespan via InsIGF-1 Signaling in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-483786
Modern Language Association (MLA)
Yazaki, Koumei…[et al.]. Supplemental Cellular Protection by a Carotenoid Extends Lifespan via InsIGF-1 Signaling in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-483786
American Medical Association (AMA)
Yazaki, Koumei& Yoshikoshi, Chinatsu& Oshiro, Satoru& Yanase, Sumino. Supplemental Cellular Protection by a Carotenoid Extends Lifespan via InsIGF-1 Signaling in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-483786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483786