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Alternative Splicing : A Potential Source of Functional Innovation in the Eukaryotic Genome
Joint Authors
Urrutia, Araxi O.
Chen, Lu
Tovar-Corona, Jaime M.
Source
International Journal of Evolutionary Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alternative splicing (AS) is a common posttranscriptional process in eukaryotic organisms, by which multiple distinct functional transcripts are produced from a single gene.
The release of the human genome draft revealed a much smaller number of genes than anticipated.
Because of its potential role in expanding protein diversity, interest in alternative splicing has been increasing over the last decade.
Although recent studies have shown that 94% human multiexon genes undergo AS, evolution of AS and thus its potential role in functional innovation in eukaryotic genomes remain largely unexplored.
Here we review available evidence regarding the evolution of AS prevalence and functional role.
In addition we stress the need to correct for the strong effect of transcript coverage in AS detection and set out a strategy to ultimately elucidate the extent of the role of AS in functional innovation on a genomic scale.
American Psychological Association (APA)
Chen, Lu& Tovar-Corona, Jaime M.& Urrutia, Araxi O.. 2012. Alternative Splicing : A Potential Source of Functional Innovation in the Eukaryotic Genome. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483789
Modern Language Association (MLA)
Chen, Lu…[et al.]. Alternative Splicing : A Potential Source of Functional Innovation in the Eukaryotic Genome. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483789
American Medical Association (AMA)
Chen, Lu& Tovar-Corona, Jaime M.& Urrutia, Araxi O.. Alternative Splicing : A Potential Source of Functional Innovation in the Eukaryotic Genome. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483789