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Bone Health in Patients with Multiple Sclerosis
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a gait disorder characterized by acute episodes of neurological defects leading to progressive disability.
Patients with MS have multiple risk factors for osteoporotic fractures, such as progressive immobilization, long-term glucocorticoids (GCs) treatment or vitamin D deficiency.
The duration of motor disability appears to be a major contributor to the reduction of bone strength.
The long term immobilization causes a marked imbalance between bone formation and resorption with depressed bone formation and a marked disruption of mechanosensory network of tightly connected osteocytes due to increase of osteocyte apoptosis.
Patients with higher level of disability have also higher risk of falls that combined with a bone loss increases the frequency of bone fractures.
There are currently no recommendations how to best prevent and treat osteoporosis in patients with MS.
However, devastating effect of immobilization on the skeleton in patients with MS underscores the importance of adequate mechanical stimuli for maintaining the bone structure and its mechanical competence.
The physical as well as pharmacological interventions which can counteract the bone remodeling imbalance, particularly osteocyte apoptosis, will be promising for prevention and treatment of osteoporosis in patients with MS.
American Psychological Association (APA)
Zikan, Vit. 2011. Bone Health in Patients with Multiple Sclerosis. Journal of Osteoporosis،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-483794
Modern Language Association (MLA)
Zikan, Vit. Bone Health in Patients with Multiple Sclerosis. Journal of Osteoporosis No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-483794
American Medical Association (AMA)
Zikan, Vit. Bone Health in Patients with Multiple Sclerosis. Journal of Osteoporosis. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-483794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483794