Expression Pattern of Peroxisome Proliferator-Activated Receptors in Rat Hippocampus following Cerebral Ischemia and Reperfusion Injury
Joint Authors
Wan, Jinyuan
Tang, Yong
Zhang, Yunmei
Jiang, Rong
Zhang, Yanli
Yang, Junqing
Zhuang, Ruichun
Jiang, Qingsong
He, Qin
Wang, Hong
Luo, Ying
Li, Yong
Yu, Huarong
Li, Yu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The present study was designed to investigate the pattern of time-dependent expression of peroxisome proliferator-activated receptors (PPARα, β, and γ) after global cerebral ischemia and reperfusion (I/R) damage in the rat hippocampus.
Male Sprague Dawley (SD) rats were subjected to global cerebral I/R.
The rat hippocampi were isolated to detect the expression of PPARs mRNA and protein levels at 30 min–30 d after I/R by RT-PCR and Western blot analysis, respectively.
The expression levels of PPARs mRNA and protein in the rat hippocampus significantly increased and peaked at 24 h for PPARα and γ (at 48 h for PPARβ) after I/R, then gradually decreased, and finally approached control levels on d 30.
The present results suggest that global cerebral I/R can cause obvious increases of hippocampal PPARs mRNA and protein expression within 15 d after I/R.
These findings may help to guide the experimental and clinical therapeutic use of PPARs agonists against brain injury.
American Psychological Association (APA)
Wang, Hong& Jiang, Rong& He, Qin& Zhang, Yunmei& Zhang, Yanli& Li, Yong…[et al.]. 2012. Expression Pattern of Peroxisome Proliferator-Activated Receptors in Rat Hippocampus following Cerebral Ischemia and Reperfusion Injury. PPAR Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483805
Modern Language Association (MLA)
Wang, Hong…[et al.]. Expression Pattern of Peroxisome Proliferator-Activated Receptors in Rat Hippocampus following Cerebral Ischemia and Reperfusion Injury. PPAR Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483805
American Medical Association (AMA)
Wang, Hong& Jiang, Rong& He, Qin& Zhang, Yunmei& Zhang, Yanli& Li, Yong…[et al.]. Expression Pattern of Peroxisome Proliferator-Activated Receptors in Rat Hippocampus following Cerebral Ischemia and Reperfusion Injury. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483805