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Clozapine Augments Delta, Theta, and Right Frontal EEG Alpha Power in Schizophrenic Patients
Joint Authors
Galin, H.
Brunet, D.
Lawson, J. S.
MacCrimmon, D.
Criollo, M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To explore the Quantitative EEG (QEEG) effects of established clozapine therapy regimes compared to those of previous ineffective antipsychotic regimes among 64 chronic (DSM-IV) schizophrenic patients.
Methods.
Data from 20 EEG channels referenced to linked ears were collected before and during maintenance clozapine therapy (mean duration 1.4 years).
Absolute power was calculated in six frequency bands: delta (0.4–3.6 Hz), theta (4.2–7.8 Hz), alpha (8.2–11.8 Hz), beta1 (12.2–15.8 Hz), beta2 (16.2–19.8 Hz), and beta3 (20.2–23.8 Hz).
Results.
Clozapine augments power globally in the delta and theta bands, but this effect is more pronounced over frontal areas.
Beta3 power was reduced.
Alpha showed a frontal increase, more pronounced in the right, coupled with a posterior decrease with no net change in overall power.
Conclusion.
The demonstration of a significant clozapine-induced alpha topographic shift frontally and to the right is a novel discovery that may serve to encourage further investigations of subcortical structures in attempts to better understand the diverse aetiologies and optimal treatments of the schizophrenias.
American Psychological Association (APA)
MacCrimmon, D.& Brunet, D.& Criollo, M.& Galin, H.& Lawson, J. S.. 2012. Clozapine Augments Delta, Theta, and Right Frontal EEG Alpha Power in Schizophrenic Patients. ISRN Psychiatry،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483811
Modern Language Association (MLA)
MacCrimmon, D.…[et al.]. Clozapine Augments Delta, Theta, and Right Frontal EEG Alpha Power in Schizophrenic Patients. ISRN Psychiatry No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-483811
American Medical Association (AMA)
MacCrimmon, D.& Brunet, D.& Criollo, M.& Galin, H.& Lawson, J. S.. Clozapine Augments Delta, Theta, and Right Frontal EEG Alpha Power in Schizophrenic Patients. ISRN Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-483811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483811