The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening
Joint Authors
Gu, Qiaoli
Yang, Huilin
Shi, Qin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Wear particle-induced periprosthetic osteolysis remains the principal cause of aseptic loosening of orthopaedic implants.
Monocytes/macrophages phagocytose wear particles and release cytokines that induce inflammatory response.
This response promotes osteoclast differentiation and osteolysis.
The precise mechanisms by which wear particles are recognized and induce the accumulation of inflammatory cells in the periprosthetic tissue have not been fully elucidated.
Recent studies have shown that toll-like receptors (TLRs) contribute to the cellular interaction with wear particles.
Wear particles are recognized by monocytes/macrophages through TLRs coupled with the adaptor protein MyD88.
After the initial interaction, wear particles induce both local and systemic migration of monocytes/macrophages to the periprosthetic region.
The cellular migration is mediated through chemokines including interleukin-8, macrophage chemotactic protein-1, and macrophage inhibitory protein-1 in the periprosthetic tissues.
Interfering with chemokine-receptor axis can inhibit cellular migration and inflammatory response.
This paper highlights recent advances in TLR, and chemokine participated in the pathogenesis of aseptic loosening.
A comprehensive understanding of the recognition and migration mechanism is critical to the development of measures that prevent wear particle-induced aseptic loosening of orthopaedic implants.
American Psychological Association (APA)
Gu, Qiaoli& Shi, Qin& Yang, Huilin. 2012. The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-483844
Modern Language Association (MLA)
Gu, Qiaoli…[et al.]. The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-483844
American Medical Association (AMA)
Gu, Qiaoli& Shi, Qin& Yang, Huilin. The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-483844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483844