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Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis
Joint Authors
Viswanathan, Balaji
Garza, Armandina
Tweardy, David J.
Weinstock, Joel
Robinson, Prema
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cysticercosis is an infection with larval cysts of the cestode Taenia solium.
Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that, in the brain, causes seizures.
Substance P (SP), a neuropeptide involved in pain-transmission, contributes to inflammation and previously was detected in granulomas associated with dead T.
crassiceps cysts.
To determine if SP contributes to granuloma formation, we measured granuloma-size and levels of IL-1β, TNF-α, and IL-6 within granulomas in T.
crassiceps-infected wild type (WT) mice and mice deficient in SP-precursor (SPP) or the SP-receptor (neurokinin 1, NK1).
Granuloma volumes of infected SPP- and NK1-knockout mice were reduced by 31 and 36%, respectively, compared to WT mice (P<.05 for both) and produced up to 5-fold less IL-1β, TNF-α, and IL-6 protein.
Thus, SP signaling contributes to granuloma development and proinflammatory cytokine production in T.
crassiceps infection and suggests a potential role for this mediator in human cystercercosis.
American Psychological Association (APA)
Garza, Armandina& Tweardy, David J.& Weinstock, Joel& Viswanathan, Balaji& Robinson, Prema. 2010. Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-483863
Modern Language Association (MLA)
Garza, Armandina…[et al.]. Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-483863
American Medical Association (AMA)
Garza, Armandina& Tweardy, David J.& Weinstock, Joel& Viswanathan, Balaji& Robinson, Prema. Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-483863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483863