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Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines
Joint Authors
Oliveira, Paula
Li, Xueli
Zhou, Jun
Bepler, Gerold
Chen, Zhengming
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
RRM1 is a determinant of gemcitabine efficacy in cancer patients.
However, the precision of predicting tumor response based on RRM1 levels is not optimal.
We used gene-specific overexpression and RNA interference to assess RRM1's impact on different classes of cytotoxic agents, on drug-drug interactions, and the modulating impact of other molecular and cellular parameters.
RRM1 was the dominant determinant of gemcitabine efficacy in various cancer cell lines.
RRM1 also impacted the efficacy of other antimetabolite agents.
It did not disrupt the interaction of two cytotoxic agents when combined.
Cell lines with truncation, deletion, and null status of p53 were resistant to gemcitabine without apparent relationship to RRM1 levels.
Pemetrexed and carboplatin sensitivity did not appear to be related to p53 mutation status.
The impact of p53 mutations in patients treated with gemcitabine should be studied in prospective clinical trials to develop a model with improved precision of predicting drug efficacy.
American Psychological Association (APA)
Zhou, Jun& Oliveira, Paula& Li, Xueli& Chen, Zhengming& Bepler, Gerold. 2010. Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-483865
Modern Language Association (MLA)
Zhou, Jun…[et al.]. Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines. Journal of Nucleic Acids No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-483865
American Medical Association (AMA)
Zhou, Jun& Oliveira, Paula& Li, Xueli& Chen, Zhengming& Bepler, Gerold. Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-483865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483865