Levels of CaV1.2 L-Type Ca2+ Channels Peak in the First Two Weeks in Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase through Development

Joint Authors

Kramer, Audra A.
Sharpe, Emily J.
Mynlieff, Michelle
Ingraham, Nicholas E.

Source

Journal of Signal Transduction

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-10-14

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system.

Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled receptors such as GABAB receptors.

Of the four isoforms of L-type channels, only CaV1.2 and CaV1.3 are predominately expressed in the nervous system.

Both isoforms are inhibited by the same pharmacological agents, so it has been difficult to determine the role of specific isoforms in physiological processes.

In the present study, Western blot analysis and confocal microscopy were utilized to study developmental expression levels and patterns of CaV1.2 and CaV1.3 in the CA1 region of rat hippocampus.

Steady-state expression of CaV1.2 predominated during the early neonatal period decreasing by day 12.

Steady-state expression of CaV1.3 was low at birth and gradually rose to adult levels by postnatal day 15.

In immunohistochemical studies, antibodies against CaV1.2 and CaV1.3 demonstrated the highest intensity of labeling in the proximal dendrites at all ages studied (P1–72).

Immunohistochemical studies on one-week-old hippocampi demonstrated significantly more colocalization of GABAB receptors with CaV1.2 than with CaV1.3, suggesting that modulation of L-type calcium current in early development is mediated through CaV1.2 channels.

American Psychological Association (APA)

Kramer, Audra A.& Ingraham, Nicholas E.& Sharpe, Emily J.& Mynlieff, Michelle. 2012. Levels of CaV1.2 L-Type Ca2+ Channels Peak in the First Two Weeks in Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase through Development. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483876

Modern Language Association (MLA)

Kramer, Audra A.…[et al.]. Levels of CaV1.2 L-Type Ca2+ Channels Peak in the First Two Weeks in Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase through Development. Journal of Signal Transduction No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-483876

American Medical Association (AMA)

Kramer, Audra A.& Ingraham, Nicholas E.& Sharpe, Emily J.& Mynlieff, Michelle. Levels of CaV1.2 L-Type Ca2+ Channels Peak in the First Two Weeks in Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase through Development. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483876

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-483876